room, just flip a coin. If pool partying is your thing, I'd give the nod to MGM. They have crazy pool parties. The character of the group that you're going with determines a lot. If its a bachelor party/group of buds and you don't give a rip about catching a wink of sleep, by all means, Luxor and MGM will suffice.
If you care about amenities, you should be choosing between Aria, Cosmopolitan, Wynn/Encore, Bellagio and the Venetian.